Director: Your brother could be anywhere. Even ..

Director: Your brother could be anywhere. Even ... Detroit.
Homer: I know he could be <anywhere>,
that's why I want you to narrow it down! Please!
Director: You know, Mr. Simpson, if you ask me, the city of
love isn't Philadelphia, it's ... Detroit.
Homer: Well, if you asked me, changing the subject makes you the
most worthess, heartless excuse for a human being I ever...
Director: Read between the lines, Mr. Simpson!
Homer: Oh, I get it! Okay. Here's twenty bucks. Now will you
tell me where my brother lives?
-- visit to the orphanage, "Oh Brother, Where Art Thou?"

Related:

• Director: I know how you feel, Mr. Simpson. I myself have spent years searching for <my> long-lost twin brother.
  Homer: Yeah yeah yeah. Well, I wish I could help...
• Herbert: And I want to pay you $200,000 a year! Homer:
  And I want to let you! -- hiring Homer as a consultant...
• Burns: Now before we begin, let me make one thing clear for you.
  I want your legal advice. I even pay for it. But...
• Jacques: First, you must get to know your lane. Feel the slickness,
  feel the slippery finish. Caresses it, experience it...
• Homer: This makes me special, Dad. Since I'm the one you kept,
  that must mean you really loved me. Grampa...
• Quiet, you kids! If I hear one more word, Bart doesn't get to watch cartoons and Lisa doesn't get to go to college.
  Homer Simpson Oh Brother, Where Art Thou...
• Granma: Abe, I want Homer to grow up respecting his father.
  He must never know about that, that carnival incident...
• Herb: I want you to help me design a car. A car for all the Homer Simpsons out there!
  And I want to pay you two hundred thousand dollars...
• Grampa: Pull your chair closer, my son. Homer: What is it,
  Dad? Grampa: Peeyoo! Not that close! Sheesh. ...

From the same category:

• Bart: If you don't watch the violence, you'll never get desensitized to it.
  Lisa: [covering her eyes] Please tell me when the scary...
• Marge: And a bottle of aspirin. Apu: [holding a bottle that can't hold more than 10 tablets] The aspirin is $24.95.
  Marge: $24.95?! Apu: I lowered the price because...
• Bart: Way to guard the parking lot, Top Gun. Guard:
  I have three medals for this. -- Heroism at its finest...
• Ned: [gets sweater caught in a nail] Ooh, looks like a loose nail.
  Homer: Yeah, one out of twenty five ain't bad! [hammers...
• Well, I just fell like filling the house with the rich satisfying smell of tobacco.
  Marge, our new spokeperson, "El Viaje Misterioso...